The primary end point is progression-free survival. In both treatment arms, disease response (assessed by International Workshop on Chronic Lymphocytic Leukemia criteria) and minimal residual disease will be used to guide therapy duration, with all patients ultimately discontinuing treatment after a maximum of 2 years.
#Majestic trials trial
The wizard successfully casting a Befriend spell on the cow would be one method not requiring a fight.Here we describe the rationale and design of MAJIC, a phase III, prospective, multicenter, randomized trial comparing the combination of the BTK inhibitor acalabrutinib plus the BCL2 inhibitor venetoclax versus the combination of venetoclax plus obinutuzumab as frontline treatment for chronic lymphocytic leukemia or small lymphocytic lymphoma. The bat cannot move until the cow has had its turn or melee is resolved. This means the bat is now engaged (see the notification at the top of the control bar). In this example, the wizard's allied bat has landed and then moved into a tile adjacent to the cow. There are various circumstances that can break engagement, but those are better discovered through playing the game than being explained in this basic guide. Usually this means that the creature that moved is unable to move again until the melee is resolved or the opposing creature's turn has ended. When a creature moves into an adjacent tile of an opposing creature, it becomes engaged. Note how both the bat and wizard are displayed together in the control bar, because the bat is in the same tile as the wizard, which has now been selected. With the bat selected, when the tile the wizard was in was clicked, the bat moved to the tile, instead of the wizard being selected. The bat is flying, which means it can occupy the same tile as the wizard, who isn't flying. The wizard's head has not turned into a bat in this example. Otherwise you may just move the currently selected creature.Īlternatively, press TAB to select the next controllable creature, or use the buttons available at the bottom of the control bar. Tougher terrain costs more APs to move into.īe warned! Creatures can occupy the same tile in some circumstances, so it is always wise to deselect the currently selected creature (by pressing ESC) before left-clicking on another creature to select it.
Some terrain is harder to move through or over than other terrain.
Sometimes you are going to want to save some APs for other stuff, like casting spells, so choose carefully just how far you decide to move a creature. You then click on the destination tile, and the selected creature will move to that tile.Īn example of a valid path being highlighted. A valid path will be highlighted, as far as the selected creature has Action Points to move. The same procedure is used to select a destination tile for a selected creature to move to.įor example: To move a currently selected creature, you move the cursor to a destination tile. The wizard only knows about it because their allied bat has LOS and ROS to it.Ī context-sensitive cursor (see the first diagram) is moved around the play area and then a left click made to select a creature or tile, or to carry out an action on that creature or tile. In this example, the wizard does have LOS to the Cow, but not ROS. The wizard does have direct LOS on the citizen in the building with the door open nearby. However, the wizard does not have direct LOS. Here, the wizard's controlled bat has LOS on an Assassin through a window. Whilst your wizard knows about anything a controlled ally can see, your wizard can only cast ranged spells at tiles and creatures they have direct LOS and ROS to themselves. It may not still be here next time you can see the tile.īecause the range of sight (ROS) varies from creature to creature, that means that it is not guarenteed that your wizard has a direct line of sight (LOS) to something an ally can see. The Fire Golem (top right) is a 'memory'. This is no guarentee that that is where the creature will stay - it's just the last known location. Usually any potentially hostile creatures that end up in the FOW will be 'remembered' - a motionless icon will remain displayed. The same tile that can be currently seen. How far a creature can see varies from creature to creature.Īny tile your wizard or their allies hasn't seen yet will be black - 'undiscovered territory'.Īny tile your wizard or allies have seen but cannot currently see (is out of sight) falls into the 'fog of war (FOW)'.
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